In the News

MILLENNIUM PUBLISHES MLN4924 PRECLINICAL DATA IN NATURE

We've had a longstanding interest in the enzymes that regulate protein homeostasis.

Protein Homeostasis and MLN4924 Further Confirms the Leadership of Millennium in Ubiquitin Proteasome System Research
Millennium is recognized as the scientific leader in protein homeostasis, a research area that has its roots in Nobel-Prize winning science. There are a variety of disease states, notably cancer, in which the homeostatic balance of cellular proteins can be altered permanently, threatening survival of the host.

Protein homeostasis is today what kinases were to the science of drug development in the mid-eighties. It opens a similarly vast frontier for drug development for many disease states with special emphasis in anti-cancer therapeutics. The success of VELCADE has validated this area of exploration. The success of pre-clinical work reported in Nature for MLN4924 is another proof point of Millennium's commitment to fully exploring this area of discovery, and the now ongoing Phase I clinical study of MLN4924 in patients with cancer to investigate the safety of this investigational drug.

Our ongoing collaboration with Harvard Medical School to conduct joint research in protein homeostasis will build on the already significant expertise of both institutions, accelerating our R&D in this important area of cancer biology.

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