For information about Millennium-sponsored clinical trials of therapies for cancer, call 1-866-VELCADE.

Just as cancer is not a single disease, controlling cancer involves many different treatment strategies, including drugs, surgery, and radiation. Most current cancer therapies are largely "shotgun" approaches that blast away at tumors but also damage healthy tissues and often have serious side effects.

At Millennium, we know that managing cancer will require the development of new treatments based not on one-size-fits-all-patients approaches, but on a thorough understanding of the intricate machinery of the many different forms of the disease. Armed with detailed blueprints of cancer cells that have been assembled from meticulous investigation in the laboratory and in the clinic, Millennium researchers are identifying the key structures and circuits that can be blocked to slow, halt, or even reverse the transformation of normal cells into cancer cells. With their new understanding of the human genetic map and of the complex interplay of factors that lead to cancer, our scientists are re-defining cancer research and drug development.

Millennium has one approved cancer drug, VELCADE^® (bortezomib) for Injection, and several more investigational drugs in our development pipeline. These compounds are just the first fruits of years of intensive discovery research.

The following are some of the forms of cancer for which scientists are investigating new therapies:

Colorectal cancer is the third most frequently diagnosed form of cancer in the United States (when all forms of skin cancer are excluded). The American Cancer Society (ACS) estimates that about 105,500 new cases of colon cancer and 42,000 new cases of rectal cancer will be diagnosed in 2003. Colorectal cancers can be highly curable, if caught early, with 90% of patients who are promptly diagnosed living at least 5 years after diagnosis.

Lung cancer is still one of the most prevalent forms of cancer, despite decades of anti-smoking initiatives. Close to 172,000 new cases of lung cancer were expected in the United States in 2003, according to ACS estimates.

For more information on lung cancer clinical trials click here.

For more information on sites participating in lung cancer clinical trials click here.

Multiple myeloma, the second most prevalent cancer of the bloodstream, accounts for about 1% of all cancers, according to the ACS, which estimates that 14,600 Americans will develop the cancer during 2003.

Non-Hodgkin's lymphoma (NHL) has been increasing in incidence worldwide during the last 40 years and accounts for 4% of all cancer diagnoses. An estimated 53,000 new cases are diagnosed annually in the United States (with a similar number estimated for the European Union). Mantle cell lymphoma (MCL) is a relatively rare type of B-cell NHL. MCL accounts for approximately 5% to 8% of all diagnoses.

For more information on NHL and MCL clinical trials click here.

For more information on sites participating in MCL clinical trials click here.

Ovarian cancer is expected by the ACS to be diagnosed in over 25,000 American women during 2003.

Prostate cancer is one of the most common forms of cancer in men, with over 220,000 new cases expected in the United States during 2003.

Millennium researchers are currently investigating several novel methods for treating cancers, including targeting monoclonal antibodies designed to deliver chemotherapy directly to tumor cells as well as several different strategies for disrupting cancer cells at various stages of their growth.

For more information on sites participating in prostate cancer clinical trials click here.

For information about Millennium-sponsored clinical trials of therapies for cancer, call 800-589-9005.

Information about clinical research studies can also be found at http://www.clinicaltrials.gov

Patients with questions about various forms of cancer and their treatment can find valuable information, including free, downloadable reprints about them at the following sites:

Association of Cancer Online Resources
www.acor.org

Cancer Care, Inc.
1-800-813-4673
www.cancercare.org

International Myeloma Foundation
1-800-452-2873
www.myeloma.org/

Leukemia and Lymphoma Society
1-800-955-4572
www.leukemia-lymphoma.org

Leukemia Research Foundation
1-800-235-6848
www.lymphoma.org

Multiple Myeloma Research Foundation
1-203-972-1250
www.multiplemyeloma.org/

The National Coalition for Cancer Survivorship
1-301-650-9127
www.canceradvocacy.org/

Wellness Community
1-800-793-WELL
www.thewellnesscommunity.org