Our Approach
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joe bolen
Innovation has a critical human dimension beyond just the science. It is the combination of the two that is the underlying factor of our success in drug discovery.

Joseph Bolen, Ph.D.
Chief Scientific Officer
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We are a global team of scientists wholly dedicated to the study of cancer. We have a pipeline of more than 13 investigational candidates that address a wide range of cancers.

We fully recognize that progress against cancer is a daunting task. Despite extensive effort in both the public and private sectors, curing cancer is likely to remain an elusive goal for some time to come. Yet we thrive on both the challenge and hope of doing our part to make that goal a reality.

Our approach focuses on medicines that are either unprecedented in their approach to cancer or that offer a best-in-class advantage. We believe this higher-powered level of scientific endeavor is more than an exercise in "drug engineering." It demands personal determination on the part of our scientists and an intolerance of conventional wisdom.

Our oncology capabilities encompass both small molecule and antibody drugs so that we can select the most appropriate candidates to achieve the desired therapeutic effect. We are excited by the possibilities, and driven forward by our sense of urgency to advance the care of cancer patients.

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pete smith
We get involved in each other's science, and that's a good thing. Our level of mutual respect invites it, and our science benefits from it.

Pete Smith, Ph.D.
SVP Non-Clinical Development Sciences
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Protein Homeostasis: Applying New Understanding of Disease Biology

Millennium is recognized as the scientific leader in protein homeostasis, a research area that has its roots in Nobel-Prize winning science. There are a variety of disease states, notably cancer, in which the homeostatic balance of cellular proteins can be altered permanently, threatening survival of the host.

Protein homeostasis is today what kinases were to the science of drug development in the mid-eighties. It opens a similarly vast frontier for drug development for many disease states with special emphasis in anti-cancer therapeutics.

Our collaboration with Harvard Medical School to conduct joint research in protein homeostasis will build on the already significant expertise of both institutions, accelerating our R&D in this important area of cancer biology.

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nancy simonian
Our scientific collaboration starts at the top by having three highly interactive R&D leaders. We benefit tremendously from team dynamics.

Nancy Simonian, M.D.
Chief Medical Officer
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Our science differentiates itself with its transformational quality. This demands a unique type of scientific talent who:

  • » Adhere to a purist insistence on what is either novel or a best-in-class improvement
  • » Comprise a true network of minds that are often challenging but always invigorating
  • » Demonstrate the courage to pursue disruptive ideas and powerful hunches
  • » Deliver the "whatever it takes" devotion necessary to make this type of innovation happen

Our science begins and ends with our mission to make a real difference in the lives of people with cancer. It is for them that we passionately devote ourselves to the task before us.

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